What is sample size and why is it important?
Determining the appropriate number of participants or units of analysis is a critical step in the design of any research. An accurate sample size calculation not only optimizes resources but also ensures the validity and reliability of the results, allowing for solid inferences about the target population. This blog explores the fundamental concepts behind sample size and its importance in research.
Ph.D Andrea Millán
5/8/20243 min read


A fundamental aspect of research methodology is the estimation or calculation of the sample size—that is, the number of participants or observations needed to achieve the study’s objectives. The first question that usually arises is: what is the purpose of calculating the sample size?
In simple terms, it helps determine how many individuals need to be studied in order to:
Estimate a population parameter with a desired level of confidence.
Detect a difference between groups, if one truly exists.
This is no small matter: including too many subjects can increase the cost of the study and waste resources, while an insufficient sample size can lead to imprecise results or even fail to detect real differences, potentially leading to incorrect conclusions.
How is sample size calculated?
The calculation depends on several factors:
The type of study (descriptive, comparative, correlational, etc.).
The main objective (estimation of proportions, means, comparison between groups).
The desired significance level (usually 5%).
The statistical power (generally 80% or 90%).
The effect size expected to be detected.
The variability of the variable of interest.
There are specific formulas for each type of study, and software is also available to automate these calculations, but professional judgment remains essential to interpret and adapt these results to each particular context.


What is sample size and why is it important?
How do we define the sample size?
How to ensure a representative and adequate sample?


Having the correct “n” is not enough. It is also essential for the sample to be representative of the target population. To achieve this, it is necessary to:
Choose an appropriate sampling method (random, stratified, cluster, etc.).
Avoid selection bias.
Consider possible losses or non-responses (and adjust the sample size accordingly).
A properly designed sample is the foundation for obtaining reliable and generalizable results.


The margin of error indicates how much the study results may vary from the true population value. The smaller we want this margin to be, the larger the sample size must be.
The confidence interval, usually set at 95%, provides a range within which the true population value is likely to lie. A higher confidence level also requires a larger sample size.
Both concepts are directly related to the precision and reliability of the study’s results.
What role do the margin of error and confidence interval play?
Having an adequate sample size is an essential step in the design of any research. It is not just about meeting a statistical requirement, but about ensuring that the results obtained are valid, accurate, and applicable to the target population.
A well-calculated sample allows for optimal use of resources, minimizes risks, and increases the reliability of the findings. In this sense, sample size calculation is a strategic tool in the planning of rigorous scientific studies.
Where to Find Professional Sample Size Calculation Services?
For those seeking technical support and methodological precision, Biomedical-Data offers a specialized sample size calculation service, tailored to different types of studies and research needs. The company stands out for its professionalism, personalized attention, and highly competitive rates, making it a strategic partner for researchers, students, and businesses looking to optimize their resources and ensure the statistical validity of their projects.
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